Clinical Metagenomic Sequencing for Species Identification and Antimicrobial Resistance Prediction in Orthopedic Device Infection
Street TL., Sanderson ND., Kolenda C., Kavanagh J., Pickford H., Hoosdally S., Cregan J., Taunt C., Jones E., Oakley S., Atkins BL., Dudareva M., McNally MA., O’Grady J., Crook DW., Eyre DW.
Diagnosis of orthopedic device-related infection is challenging, and causative pathogens may be difficult to culture. Metagenomic sequencing can diagnose infections without culture, but attempts to detect antimicrobial resistance (AMR) determinants using metagenomic data have been less successful.