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The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.

Type

Journal article

Journal

Gut

Publication Date

02/1987

Volume

28

Pages

186 - 189

Keywords

Bacteria, Colitis, Ulcerative, Colon, Feces, Female, Humans, Immunoglobulin A, Immunoglobulin A, Secretory, Intestinal Mucosa, Male, Peptide Hydrolases, Serine Endopeptidases