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Air in the pleural cavity is termed pneumothorax. When this occurs in the absence of trauma or medical intervention, it is called spontaneous pneumothorax. Primary spontaneous pneumothorax typically occurs in young patients without known lung disease. However, the idea that these patients have "normal" lungs is outdated. This article will review evidence of inflammation and respiratory bronchiolitis on surgical specimens, discuss the identification of emphysema-like change (i.e., blebs and bullae), the concept of pleural porosity and review recent data on the overexpression of matrix metalloproteinases in the lungs of patients who have had pneumothorax.

Original publication

DOI

10.3390/jcm11030490

Type

Journal article

Journal

Journal of clinical medicine

Publication Date

19/01/2022

Volume

11

Addresses

Respiratory Trials Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital, NHS Trust, Oxford OX3 7LJ, UK.