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The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

Original publication

DOI

10.1128/AAC.49.4.1622-1625.2005

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

04/2005

Volume

49

Pages

1622 - 1625

Keywords

Administration, Oral, Adolescent, Adult, Aged, Animals, Antimalarials, Artemisinins, Artesunate, Doxycycline, Drug Therapy, Combination, Female, Humans, Malaria, Falciparum, Male, Middle Aged, Plasmodium falciparum, Sesquiterpenes, Severity of Illness Index