Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.
Newton PN., Chaulet J-F., Brockman A., Chierakul W., Dondorp A., Ruangveerayuth R., Looareesuwan S., Mounier C., White NJ.
The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.