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Fluoroquinolone and cephalosporin use in healthcare settings has triggered outbreaks of high-mortality, multidrug-resistant C. difficile infection. Here, we identify a mechanism associated with raised cephalosporin MICs in C. difficile comprising amino acid substitutions in two cell wall transpeptidase enzymes (penicillin binding proteins).

Original publication

DOI

10.1128/mbio.00243-23

Type

Journal article

Journal

mBio

Publisher

American Society for Microbiology

Publication Date

05/04/2023