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Human colonic intraepithelial lymphocytes have been shown to suppress the proliferation of autologous lamina propria lymphocytes and allogeneic peripheral blood mononuclear cells. This study has shown that, in vitro, intraepithelial lymphocytes suppress IgA and total immunoglobulin synthesis (but not IgG or IgM production) by autologous peripheral blood and lamina propria lymphocytes. This down regulation of IgA production is mediated by a soluble factor secreted by the intraepithelial lymphocytes. There is no difference in immunoglobulin down regulation by intraepithelial lymphocytes of control subjects and patients with inflammatory bowel disease.

Type

Journal article

Journal

Gut

Publication Date

02/1993

Volume

34

Pages

257 - 263

Keywords

Adolescent, Adult, Aged, Cell Division, Cells, Cultured, Colon, Down-Regulation, Epithelium, Female, Humans, Immune Tolerance, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunoglobulins, Inflammatory Bowel Diseases, Male, Middle Aged, T-Lymphocytes