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Although apparently dissimilar in both structure and function, the gut and locomotor system are linked by a number of clinical syndromes in which both are involved. In inflammatory bowel disease, intestinal mucosal inflammation is the primary problem, but may be associated with both axial and peripheral arthropathies. In the seronegative spondyloarthropathies the primary problem is in the locomotor system, but intestinal abnormalities may also be present. In addition, non-steroidal anti-inflammatory drugs used in their treatment, may cause a distinct enteropathy which may be confused with the disease-related intestinal abnormalities. The clinical, histological and genetic features of these conditions are examined in order to assess their relationship and the central role of the intestinal mucosa in their pathogenesis.

Original publication

DOI

10.1111/j.1365-2036.1997.tb00804.x

Type

Journal article

Journal

Alimentary pharmacology & therapeutics

Publication Date

12/1997

Volume

11 Suppl 3

Pages

10 - 15

Addresses

Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK.

Keywords

Intestinal Mucosa, Humans, Spondylitis, Ankylosing, Arthritis, Inflammatory Bowel Diseases, Disease Susceptibility, Anti-Inflammatory Agents, Non-Steroidal, Major Histocompatibility Complex, Intestinal Absorption, Clinical Trials as Topic