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Twenty patients with severe active ulcerative colitis were entered into a pilot study to test the efficacy of pulsed high-dose methylprednisolone in inducing remission. Of 20 patients, 12 improved, but 8 of 20 patients (40%) who did not went for urgent colectomy. The group proceeding to surgery tended to have more extensive disease. These results contrast unfavorably with historical control data from this unit.

Type

Journal article

Journal

J Clin Gastroenterol

Publication Date

02/1990

Volume

12

Pages

40 - 41

Keywords

Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Colitis, Ulcerative, Drug Administration Schedule, Female, Humans, Male, Methylprednisolone, Middle Aged, Pilot Projects