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Medical records of patients with ulcerative colitis (n = 858), Crohn's disease (n = 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders. Of outpatient controls (n = 300), 2 per cent had at least one autoimmune disorder, compared to 7 per cent with ulcerative colitis, 2 per cent with Crohn's disease and 6 per cent with coeliac disease. Inclusion of primary sclerosing cholangitis with the autoimmune disorders increased the overall prevalence in ulcerative colitis to over 9 per cent. The results provide further indirect evidence of involvement of autoimmune mechanisms in the pathogenesis of ulcerative colitis.

Type

Journal article

Journal

The Quarterly journal of medicine

Publication Date

09/1989

Volume

72

Pages

835 - 840

Addresses

Gastroenterology Department, Radcliffe Infirmary, Oxford.

Keywords

Humans, Cholangitis, Sclerosing, Colitis, Ulcerative, Crohn Disease, Celiac Disease, Anemia, Hemolytic, Autoimmune, Autoimmune Diseases, Prevalence, Adult, Middle Aged, Female, Male