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Corticosteroids are of proven value for the treatment of active ulcerative colitis and Crohn's disease, but are of little value for the maintenance of remission. The development of new steroid compounds with low systemic bioavailability should allow higher doses to be given for longer periods without risking serious adverse reactions.

Type

Journal article

Journal

Gastroenterology clinics of North America

Publication Date

03/1989

Volume

18

Pages

21 - 34

Addresses

Gastroenterology Unit, Radcliffe Infirmary, Oxford.

Keywords

Humans, Colitis, Ulcerative, Crohn Disease, Adrenal Cortex Hormones, Enema, Administration, Topical, Drug Administration Schedule