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Little is known of either the etiology or the pathogenesis of nonspecific inflammatory bowel disease (IBD). One hypothesis proposes the presence of a disorder of immune regulation as an initiating or perpetuating mechanism of continued bowel wall inflammation in these diseases. This chapter examines the basis for this proposal and reviews recent studies directed toward the demonstration of defective immunoregulatory mechanisms in IBD.

Original publication

DOI

10.1146/annurev.me.34.020183.001211

Type

Journal article

Journal

Annu Rev Med

Publication Date

1983

Volume

34

Pages

195 - 204

Keywords

Antibody Formation, Antilymphocyte Serum, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Cellular, Intestinal Mucosa, Killer Cells, Natural, Monocytes, T-Lymphocytes, Regulatory