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The new oral fixed combination artemether-lumefantrine (CGP 56697) has proved to be an effective and well-tolerated treatment of multi-drug resistant Plasmodium falciparum malaria, although cure rates using the four-dose regimen have been lower than with the currently recommended alternative of artesunate-mefloquine. Two six-dose schedules (total adult dose = 480 mg of artemether and 2,880 mg of lumefantrine) were therefore compared with the previously used four-dose regimen (320 mg of artemether and 1,920 mg of lumefantrine) in a double-blind trial involving 359 patients with uncomplicated multidrug-resistant falciparum malaria. There were no differences between the three treatment groups in parasite and fever clearance times, and reported adverse effects. The two six-dose regimens gave adjusted 28-day cure rates of 96.9% and 99.12%, respectively, compared with 83.3% for the four-dose regimen (P < 0.001). These six-dose regimens of artemether-lumefantrine provide a highly effective and very well-tolerated treatment for multidrug-resistant falciparum malaria.

Original publication

DOI

10.4269/ajtmh.1999.60.936

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

06/1999

Volume

60

Pages

936 - 942

Keywords

Adolescent, Adult, Aged, Animals, Antimalarials, Artemether, Lumefantrine Drug Combination, Artemisinins, Child, Child, Preschool, DNA, Protozoan, Dose-Response Relationship, Drug, Double-Blind Method, Drug Combinations, Drug Resistance, Multiple, Ethanolamines, Female, Fluorenes, Humans, Malaria, Falciparum, Male, Middle Aged, Plasmodium falciparum, Recurrence, Sesquiterpenes, Thailand