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Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

Original publication

DOI

10.1186/1475-2875-10-113

Type

Journal article

Journal

Malar J

Publication Date

05/05/2011

Volume

10

Keywords

Adult, Antimalarials, Chloroquine, DNA, Protozoan, Drug Resistance, Female, Genotype, Humans, Malaria, Vivax, Parasitic Sensitivity Tests, Plasmodium vivax, Pregnancy, Pregnancy Complications, Infectious, Thailand