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The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis.

Original publication

DOI

10.1038/onc.2010.641

Type

Journal article

Journal

Oncogene

Publication Date

19/05/2011

Volume

30

Pages

2304 - 2306

Keywords

Cell Cycle, Cell Differentiation, Cellular Senescence, Gene Expression Regulation, Neoplastic, Humans, Melanocytes, Melanoma, Microphthalmia-Associated Transcription Factor, Neoplastic Stem Cells, Skin Neoplasms