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The past few years have seen exciting discoveries in the area of tyrosine kinase structural biology including the first high resolution models of full-length receptor tyrosine kinases and new mechanistic insights into the structural mechanisms of receptor tyrosine kinase activation. Despite being a mature area of research, the application of new technologies continues to advance our understanding. In this article we highlight a selection of recent studies that illustrate the current areas of research interest, focussing in particular on the exciting progress made possible by cryo-electron-microscopy. These new discoveries may herald a wave of new design ideas for therapeutics acting through novel mechanisms.

Original publication

DOI

10.1016/j.sbi.2023.102665

Type

Journal article

Journal

Current opinion in structural biology

Publication Date

10/2023

Volume

82

Addresses

Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK.

Keywords

Receptor Protein-Tyrosine Kinases, Tyrosine, Cryoelectron Microscopy, Molecular Biology, Protein-Tyrosine Kinases