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Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values 

Original publication

DOI

10.1038/s41467-023-41819-0

Type

Journal article

Journal

Nature communications

Publication Date

10/2023

Volume

14

Addresses

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.

Keywords

Humans, Colorectal Neoplasms, Genetic Predisposition to Disease, Risk Factors, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Ethnicity