Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.
Davenport RJ., Diaz P., Galvin FCA., Lloyd S., Mack SR., Owens R., Sabin V., Wynn J.
The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.