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HIV-2 is less pathogenic and less transmissible than HIV-1. Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-2 infection than in HIV-1 infection. These insights may be crucial to the design of effective vaccines.


Journal article


Curr Opin Immunol

Publication Date





382 - 387


AIDS Vaccines, Animals, HIV Infections, HIV-1, HIV-2, Humans, T-Lymphocytes, Vaccines, Attenuated