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22 years ago, the first cases of an acquired immunodeficiency syndrome afflicting young, homosexual American men were reported, heralding what we now know to be the beginning of the HIV epidemic. Since then, billions of US dollars have been invested in HIV research in the hope of gaining a better understanding of this infection and how to prevent and treat it. What are the landmarks in HIV research over the past two decades, and what questions still remain to be answered? What has the intense study of HIV infection taught us about other virus infections and how our immune system responds to them?

Original publication




Journal article


Nat Rev Immunol




343 - 348


Acquired Immunodeficiency Syndrome, Biomedical Research, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Disease Outbreaks, Female, HIV-1, History, 20th Century, History, 21st Century, Humans, Male, Time Factors