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6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

Type

Journal article

Journal

Lancet

Publication Date

22/02/1986

Volume

1

Pages

411 - 414

Keywords

Acute Disease, Adult, Agranulocytosis, Amodiaquine, Drug Combinations, Drug Therapy, Combination, Female, Humans, Leukocyte Count, Malaria, Male, Middle Aged, Neutropenia, Proguanil, Retrospective Studies, Sulfaguanidine, Sulfamethoxazole, Travel, Trimethoprim, Trimethoprim, Sulfamethoxazole Drug Combination