Transient synaptic CD61 pairing with CD103 increases the cytotoxicity of antigen-specific T cells
Dong T., Hamid MHBA.
The transient expression of CD61 and its unconventional pairing with CD103 at the immune synapse enhances T cell receptor signaling, improves anti-tumor cytotoxicity and mitigates tumor growth. Clinically, CD61+ tumor infiltrating lymphocytes (TILs) exhibit enhanced effector functions and show limited cellular exhaustion.