Revisiting Interleukin-12 as a Cancer Immunotherapy Agent
Berraondo P., Etxeberria I., Ponz-Sarvise M., Melero I.
Abstract IL12 antitumor activities are mediated by the activation of T and natural killer (NK) lymphocytes to produce IFNγ. Systemically, recombinant IL12 has a narrow therapeutic window that favors local delivery, for instance, by gene therapy approaches. IL12 is a powerful partner in immunotherapy combinations with checkpoint inhibitors and adoptive T-cell transfer. Clin Cancer Res; 24(12); 2716–8. ©2018 AACR. See related article by Hu et al., p. 2920