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Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-β-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.

Original publication

DOI

10.1107/S1744309111029654

Type

Journal article

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun

Publication Date

01/10/2011

Volume

67

Pages

1160 - 1164

Keywords

Biocatalysis, Crystallography, X-Ray, Klebsiella pneumoniae, Models, Molecular, Protein Structure, Tertiary, beta-Lactamases