Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.
Ishak CA., Marhon SA., Tchrakian N., Hodgson A., Loo Yau H., Gonzaga IM., Peralta M., Lungu IM., Gomez S., Liang S-B., Shen SY., Chen R., Chen J., Chatterjee B., Wanniarachchi KN., Lee J., Zehrbach N., Hosseini A., Mehdipour P., Sun S., Solovyov A., Ettayebi I., Francis KE., He A., Wu T., Feng S., da Silva Medina T., Campos de Almeida F., Bayani J., Li J., MacDonald S., Wang Y., Garcia SS., Arthofer E., Diab N., Srivastava A., Austin PT., Sabatini PJB., Greenbaum BD., O'Brien CA., Shepherd TG., Tsao MS., Chiappinelli KB., Oza AM., Clarke BA., Rottapel R., Lheureux S., De Carvalho DD.
SignificanceOur landmark discovery of viral mimicry characterized repetitive elements as immunogenic stimuli that cull cancer cells. If expressed repetitive elements cull cancer cells, why does every human cancer express repetitive elements? Our report offers an exciting advancement toward understanding this paradox and how to exploit this mechanism for cancer interception. See related commentary by Murayama and Cañadas, p. 670.