Figure 1 from Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
Diers AR., Guo Q., Li Z., Richardson E., Idris S., Willis C., Tak PP., Withers DR., Barone F.
<p>CAN-2409 + prodrug inhibits tumor growth and increases lymphocyte infiltration in MC38 tumor–bearing C57BL/6 mice. <b>A,</b> MC38 tumor–bearing mice were treated with or without CAN-2409 i.t. (red arrow) followed by 4 days of i.p. administration of prodrug (blue arrows), and tumor growth was monitored. Left, tumor growth curves. Right, tumor growth inhibition rate after treatment. <b>B,</b> Endpoint analysis of tumor mass. <b>C–G,</b> Endpoint analysis tumor immune populations assessed by flow cytometry. <i>N</i> = 7–9 mice per group (some tumors are too small to be included in the immune cell analysis). Two-tailed <i>t</i> test, *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ****, <i>P</i> < 0.0001.</p>