Current access, availability and use of antibiotics in primary care among key low- and middle-income countries and the policy implications.
Saleem Z., Mekonnen BA., Orubu ES., Islam MA., Nguyen TTP., Ubaka CM., Buma D., Thuy NDT., Sant Y., Sono TM., Bochenek T., Kalungia AC., Abdullah S., Miljković N., Yeika E., Niba LL., Akafity G., Sefah IA., Opanga SA., Kitutu FE., Khuluza F., Zaranyika T., Parajuli A., Darweesh O., Islam S., Kumar S., Nabayiga H., Jairoun AA., Chigome A., Ogunleye O., Fadare J., Massele A., Cook A., Jelić AG., Godói IPD., Phillip A., Meyer JC., Funiciello E., Lorenzetti G., Kurdi A., Haseeb A., Moore CE., Campbell SM., Godman B., Sharland M.
Antimicrobial resistance (AMR) poses a significant threat, particularly in low- and middle-income countries (LMICs), exacerbated by inappropriate antibiotic use, access to quality antibiotics and weak antimicrobial stewardship (AMS). There is a need to review current evidence on antibiotic use, access, and AMR, in primary care across key countries.Areas covered: This narrative review analyses publications from 2018 to 2024 regarding access, availability and use of appropriate antibiotics. There were very few studies focussing on a lack of access to antibiotics in primary care. However, there was considerable evidence of high rates of inappropriate antibiotic use, including Watch antibiotics, typically for minor infections, across studied countries exacerbated by patient demand. The high costs of antibiotics in a number of LMICs impacts on their use resulting in short courses and sharing of antibiotics. This can contribute to AMR alongside the use of substandard and falsified antibiotics. Overall, limited implementation of national action plans, insufficient resources, and knowledge gaps, affects sustainable development goals to provide routine access to safe, effective and appropriate antibiotics. There is a clear need to focus health policy on the optimal use of essential AWaRe antibiotics in primary care settings to reduce AMR in LMICs.