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Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.

Original publication

DOI

10.4269/ajtmh.1999.61.964

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

12/1999

Volume

61

Pages

964 - 967

Keywords

Adolescent, Adult, Antimalarials, Artemether, Artemisinins, Child, Child, Preschool, Drug Therapy, Combination, Electrocardiography, Ethanolamines, Female, Fluorenes, Heart, Humans, Lumefantrine, Malaria, Falciparum, Male, Middle Aged, Sesquiterpenes