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Human-disease etiology can be better understood with phase information about diploid sequences. We present a method for estimating haplotypes, using genotype data from unrelated samples or small nuclear families, that leads to improved accuracy and speed compared to several widely used methods. The method, segmented haplotype estimation and imputation tool (SHAPEIT), scales linearly with the number of haplotypes used in each iteration and can be run efficiently on whole chromosomes.

Original publication

DOI

10.1038/nmeth.1785

Type

Journal article

Journal

Nat Methods

Publication Date

04/12/2011

Volume

9

Pages

179 - 181

Keywords

Genome, Haplotypes