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Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient patients, severely constrains this use. Primaquine was approved more than 50 years ago after extensive clinical testing. Review of the mid-20th century literature in the light of present understanding of pharmacokinetics and metabolism suggests that manipulation of these factors might dissociate 8-aminoquinoline efficacy from toxicity and lead to an improved therapeutic index.

Original publication




Journal article


Am J Trop Med Hyg

Publication Date





1010 - 1014


Aminoquinolines, Antimalarials, Drug Interactions, Drug Therapy, Combination, Humans, Malaria, Plasmodium, Primaquine