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A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range of antimalarial drugs. Its sensitivity allowed the use of parasite densities as low as 200 parasites/microl of blood. Being a nonisotopic, colorimetric assay, it lies within the capabilities of a modest laboratory at the district level.

Original publication

DOI

10.1128/aac.48.4.1426-1429.2004

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

04/2004

Volume

48

Pages

1426 - 1429

Keywords

Animals, Antimalarials, Colorimetry, Enzyme-Linked Immunosorbent Assay, Erythrocytes, Humans, L-Lactate Dehydrogenase, Malaria, Falciparum, Nonlinear Dynamics, Plasmodium falciparum, Thailand