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In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P = .02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations.

Original publication

DOI

10.1093/infdis/jir806

Type

Journal article

Journal

J Infect Dis

Publication Date

15/02/2012

Volume

205

Pages

680 - 683

Keywords

Adult, Alleles, Cohort Studies, DNA, Protozoan, Female, Genotype, Humans, Infant, Infant, Newborn, Malaria, Vivax, Microsatellite Repeats, Molecular Typing, Plasmodium vivax, Polymerase Chain Reaction, Pregnancy, Prospective Studies, Recurrence