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Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry. The applicability of a compact and robust portable Raman spectrometer (TruScan) for the in situ chemical identification of counterfeit tablets is reported.

Original publication

DOI

10.1016/j.aca.2008.06.007

Type

Journal article

Journal

Anal Chim Acta

Publication Date

15/08/2008

Volume

623

Pages

178 - 186

Keywords

Antimalarials, Artemisinins, Artesunate, Fourier Analysis, Fraud, Mass Spectrometry, Quality Control, Reproducibility of Results, Spectrum Analysis, Raman, Tablets