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Recent results from the crystallographic studies on glycogen phosphorylase b at 2 A resolution are reviewed with special reference to other themes of the meeting. The structural similarity of the fold of 150 residues in phosphorylase to the observed in lactate dehydrogenase is discussed and the binding sites for NADH in phosphorylase are described. The binding of the potent inhibitor glucose-1,2-cyclic phosphate to phosphorylase b in the crystal has been studied at 3 A resolution. The results are compared with those previously obtained for glucose-1-phosphate and discussed with reference to proposals for a mechanism of catalysis that involves the essential cofactor pyridoxal phosphate.

Original publication

DOI

10.1098/rstb.1981.0057

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

26/06/1981

Volume

293

Pages

23 - 41

Keywords

Allosteric Regulation, Binding Sites, Catalysis, Chemical Phenomena, Chemistry, Crystallography, Enzyme Activation, Glucosephosphates, Macromolecular Substances, Models, Biological, Models, Molecular, NAD, Phosphorylase b, Phosphorylases, Protein Conformation