Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

Original publication

DOI

10.1038/ng.993

Type

Journal article

Journal

Nat Genet

Publication Date

27/11/2011

Volume

44

Pages

58 - 61

Keywords

Case-Control Studies, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 7, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Multiple Myeloma, Polymorphism, Single Nucleotide, Protein-Serine-Threonine Kinases, Risk Factors