Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
Broderick P., Chubb D., Johnson DC., Weinhold N., Försti A., Lloyd A., Olver B., Ma Y., Dobbins SE., Walker BA., Davies FE., Gregory WA., Childs JA., Ross FM., Jackson GH., Neben K., Jauch A., Hoffmann P., Mühleisen TW., Nöthen MM., Moebus S., Tomlinson IP., Goldschmidt H., Hemminki K., Morgan GJ., Houlston RS.
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.