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The efficacy and safety of the 6-dose regimen of artemether-lumefantrine were assessed in an open randomized trial in children and adults presenting with acute, uncomplicated Plasmodium falciparum malaria in Thailand between November 1997 and March 1998. 200 patients were enrolled in 2 centres: 150 received artemether-lumefantrine (i.e., a median total dose of 9.6 mg/kg [interquartile range 8.7-10.7] and 57.9 mg/kg of lumefantrine [52.4-64.0]) and 50 the standard combination of artesunate (12 mg/kg over 3 d) and mefloquine (25 mg/kg). All patients had rapid initial clinical and parasitological responses. The 28 d cure rates were high: 97.7% (95% confidence interval [95% CI] 93.5-99.5%) for artemether-lumefantrine and 100% (95% CI 92.5-100%) for artesunate-mefloquine. The 6-dose regimen of artemether-lumefantrine was better tolerated than, and as effective as, artesunate-mefloquine, the current standard treatment in this area of multidrug-resistant P. falciparum malaria.

Original publication

DOI

10.1016/s0035-9203(00)90082-8

Type

Journal article

Journal

Trans R Soc Trop Med Hyg

Publication Date

09/2000

Volume

94

Pages

545 - 548

Keywords

Adolescent, Adult, Antimalarials, Artemether, Artemisinins, Artesunate, Child, Child, Preschool, Drug Combinations, Drug Resistance, Multiple, Ethanolamines, Female, Fluorenes, Humans, Infant, Lumefantrine, Malaria, Falciparum, Male, Mefloquine, Middle Aged, Recurrence, Sesquiterpenes, Treatment Outcome