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A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.

Original publication

DOI

10.1016/j.trstmh.2005.01.008

Type

Journal article

Journal

Trans R Soc Trop Med Hyg

Publication Date

02/2006

Volume

100

Pages

184 - 186

Keywords

Antimalarials, Humans, Malaria, Falciparum, Male, Quinine, Thailand, Treatment Failure