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We have constructed and analysed somatic cell hybrids from cell lines containing balanced reciprocal translocations involving chromosome 19 and providing two new breakpoints on 19q. These and other hybrids have been tested with a series of markers from 19q to enhance the existing map. Several new cloned DNA sequences that map to 19q13.3-19qter are reported; the locus D19Z1 has been analysed by CHEF gel electrophoresis.

Type

Journal article

Journal

Hum Genet

Publication Date

05/1991

Volume

87

Pages

65 - 72

Keywords

Animals, Chromosome Aberrations, Chromosome Disorders, Chromosome Fragility, Chromosome Mapping, Chromosomes, Human, Pair 19, Cricetinae, Electrophoresis, Agar Gel, Genetic Markers, Humans, Hybrid Cells, Karyotyping, Mice, Nucleic Acid Hybridization, Translocation, Genetic