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Many of the antiretrovirals used against HIV-1 are either ineffective or less effective in HIV-2 infection. There is in vitro evidence of the potency of maraviroc and several investigational agents against HIV-2. We conclude that, whilst specific boosted protease inhibitors combined with nucleoside analogues should still be considered the mainstays of HIV-2 treatment, maraviroc, T-1249, TAK-779 and AMD3100, as well as raltegravir, could contribute to regimens for treatment-experienced individuals. Factors bearing on the use and timing of these alternative agents are discussed.

Original publication




Journal article


Antivir Ther

Publication Date





435 - 438


CCR5 Receptor Antagonists, Cyclohexanes, Female, HIV Envelope Protein gp41, HIV Fusion Inhibitors, HIV-2, Humans, Male, Peptide Fragments, Triazoles