Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors
Spencer J., Amin J., Boddiboyena R., Packham G., Cavell BE., Syed Alwi SS., Paranal RM., Heightman TD., Wang M., Marsden B., Coxhead P., Guille M., Tizzard GJ., Coles SJ., Bradner. JE.
The ferrocene analogue 4b had an IC50 = 4 nM (HDAC1), 180 nM (HDAC8) and was effective in a Xenopus model of tubulin deacetylation. Analogue 4a displayed mainly μM IC50 values against HDACs apart from HDAC6 (IC50 = 69 nM).