Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.

Original publication

DOI

10.1126/science.1098876

Type

Journal article

Journal

Science

Publication Date

20/08/2004

Volume

305

Keywords

Africa, Alleles, Animals, Antimalarials, Asia, Southeastern, Chloroquine, Drug Resistance, Drug Therapy, Combination, Evolution, Molecular, Genes, Protozoan, Genotype, Humans, Malaria, Falciparum, Microsatellite Repeats, Mutation, Plasmodium falciparum, Pyrimethamine, Tetrahydrofolate Dehydrogenase