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Two triple immunization vaccine regimens with adenoviral vectors with E1 deleted expressing Gag of human immunodeficiency virus type 1 were tested for induction of T- and B-cell-mediated-immune responses in mice and in nonhuman primates. The vaccine carriers were derived from distinct serotypes of human and simian adenoviruses that fail to elicit cross-neutralizing antibodies expected to dampen the effect of booster immunizations. Both triple immunization regimens induced unprecedented frequencies of gamma interferon-producing CD8(+) T cells to Gag in mice and monkeys that remained remarkably stable over time. In addition, monkeys developed Gag-specific interleukin-2-secreting T cells, presumably belonging to the CD4(+) T-cell subset, and antibodies to both Gag and the adenoviral vaccine carriers.

Original publication




Journal article


J Virol

Publication Date





7392 - 7399


AIDS Vaccines, Adenoviruses, Human, Animals, B-Lymphocytes, Gene Products, gag, Genetic Vectors, HIV Antibodies, HIV Infections, HIV-1, Humans, Immunization, Immunization Schedule, Immunization, Secondary, Macaca mulatta, Mice, Mice, Inbred BALB C, Species Specificity, T-Lymphocytes, Transgenes