Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Two triple immunization vaccine regimens with adenoviral vectors with E1 deleted expressing Gag of human immunodeficiency virus type 1 were tested for induction of T- and B-cell-mediated-immune responses in mice and in nonhuman primates. The vaccine carriers were derived from distinct serotypes of human and simian adenoviruses that fail to elicit cross-neutralizing antibodies expected to dampen the effect of booster immunizations. Both triple immunization regimens induced unprecedented frequencies of gamma interferon-producing CD8(+) T cells to Gag in mice and monkeys that remained remarkably stable over time. In addition, monkeys developed Gag-specific interleukin-2-secreting T cells, presumably belonging to the CD4(+) T-cell subset, and antibodies to both Gag and the adenoviral vaccine carriers.

Original publication

DOI

10.1128/JVI.78.14.7392-7399.2004

Type

Journal article

Journal

J Virol

Publication Date

07/2004

Volume

78

Pages

7392 - 7399

Keywords

AIDS Vaccines, Adenoviruses, Human, Animals, B-Lymphocytes, Gene Products, gag, Genetic Vectors, HIV Antibodies, HIV Infections, HIV-1, Humans, Immunization, Immunization Schedule, Immunization, Secondary, Macaca mulatta, Mice, Mice, Inbred BALB C, Species Specificity, T-Lymphocytes, Transgenes