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Vaccines that comprise attenuated viral vectors encoding antigens from target pathogens generate potent T-cell responses. One such pathogen is malaria, and in particular the liver stage of its life cycle. Immunogenicity and efficacy studies in animals and humans have revealed the generation of memory T cells of both the central and effector phenotypes, depending on the viral vectors used in the malaria vaccination regime (viral species and serotype, combination and sequence for prime-boost) and suggest a divergence in their protective role. Being able to influence the memory T-cell make-up in a rational manner may allow us to develop more efficacious vaccines.

Original publication

DOI

10.1111/j.1365-2567.2006.02552.x

Type

Journal article

Journal

Immunology

Publication Date

06/2007

Volume

121

Pages

158 - 165

Keywords

Adenoviridae, Animals, Genetic Vectors, Humans, Immunologic Memory, Malaria, Malaria Vaccines, Mice, Poxviridae, T-Lymphocyte Subsets