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An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.

Original publication

DOI

10.1093/bioinformatics/bti537

Type

Journal article

Journal

Bioinformatics

Publication Date

15/08/2005

Volume

21

Pages

3435 - 3438

Keywords

Algorithms, Computer Graphics, Computer Simulation, Energy Transfer, Internet, Models, Chemical, Models, Molecular, Protein Conformation, Protein Folding, Proteins, Sequence Alignment, Sequence Analysis, Protein, Software, Structure-Activity Relationship, User-Computer Interface