Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.
Norbeck O., Isa A., Pöhlmann C., Broliden K., Kasprowicz V., Bowness P., Klenerman P., Tolfvenstam T.
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.