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OBJECTIVE: To determine the efficacy and safety of oral dihydroartemisinin-piperaquine (DP, Artekin) in the treatment of uncomplicated Plasmodium falciparum malaria in southern Laos. METHODS: An open, randomized clinical trial of oral artesunate-mefloquine (AM) vs. DP in 220 patients with acute uncomplicated falciparum malaria in Savannakhet Province, Laos. RESULTS: The 42-day cure rates (95% CI), as determined by survival analysis and adjusted for reinfection, were excellent and similar for the two groups [99 (94-100)% and 100 (100-100)% for AM and DP, respectively]. The median (range) fever and parasite clearance times for the AM and DP groups were also similar [20 (4-63) h and 2 (1-4) days vs. 20 (7-57) and 2 (1-4) days, logrank P = 0.4 and 0.17, respectively]. There were more patients with at least one potential side effect following treatment in the AM group when compared with the DP group [64/110 (58%) vs. 48/110 (44%), respectively, P = 0.031]. CONCLUSION: Dihydroartemisinin-piperaquine did not have superior efficacy to AM for the treatment of uncomplicated falciparum malaria in Laos but was associated with fewer adverse effects.

Original publication

DOI

10.1111/j.1365-3156.2006.01671.x

Type

Journal article

Journal

Trop Med Int Health

Publication Date

08/2006

Volume

11

Pages

1157 - 1165

Keywords

Administration, Oral, Adolescent, Adult, Antimalarials, Artemisinins, Artesunate, Child, Drug Therapy, Combination, Female, Humans, Laos, Malaria, Falciparum, Male, Mefloquine, Parasitemia, Quinolines, Recurrence, Sesquiterpenes, Treatment Failure, Treatment Outcome