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Allelic frequencies of a (CCTTT)(n) pentanucleotide repeat in the NOS2A promoter region were determined in a total of 1393 unrelated individuals from five specific population groups in four continents: Africa, Europe, Asia, and the Caribbean. There were highly significant differences in allele frequencies between the ethnically diverse populations. The repeat variation may have implications for the selective pressure of malaria or other infectious diseases that may operate at the NOS2 locus.

Original publication

DOI

10.1006/niox.2000.0290

Type

Journal article

Journal

Nitric Oxide

Publication Date

08/2000

Volume

4

Pages

379 - 383

Keywords

Continental Population Groups, DNA, Gene Frequency, Genetic Predisposition to Disease, Humans, Infection, Microsatellite Repeats, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Polymorphism, Genetic, Promoter Regions, Genetic