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Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic variation which have involved the MHC, as well as highlighting likely future directions. As a consequence of its particular genomic structure, its remarkable polymorphism and its early implication in numerous diseases, the MHC has been considered as a model region for genomics, being the first substantial region to be sequenced and establishing fundamental concepts of linkage disequilibrium, haplotypic structure and meiotic recombination. Recently, the MHC became the first genomic region to be entirely re-sequenced for common haplotypes, while studies mapping gene expression phenotypes across the genome have strongly implicated variation in the MHC. This review shows how the MHC continues to provide new insights and remains in the vanguard of contemporary research in human genomics.

Original publication

DOI

10.1093/bfgp/elp010

Type

Journal article

Journal

Brief Funct Genomic Proteomic

Publication Date

09/2009

Volume

8

Pages

379 - 394

Keywords

Genetic Predisposition to Disease, Genomics, Humans, Linkage Disequilibrium, Major Histocompatibility Complex, Polymorphism, Genetic, Research