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Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide variation data provide evidence for a weak fixation bias in favour of G and C alleles that is strongest at the centre of inferred recombination hotspots.

Original publication

DOI

10.1042/BST0340535

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

08/2006

Volume

34

Pages

535 - 536

Keywords

Alleles, Humans, Meiosis, Mutation, Nucleotides, Polymorphism, Genetic, Recombination, Genetic