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The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC(50)) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

04/2004

Volume

70

Pages

395 - 397

Keywords

Animals, Antimalarials, Drug Resistance, Erythrocytes, Humans, Inhibitory Concentration 50, Malaria, Vivax, Plasmodium vivax, Statistics, Nonparametric, Thailand