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After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

Original publication

DOI

10.1038/ng.1080

Type

Journal article

Journal

Nat Genet

Publication Date

05/02/2012

Volume

44

Pages

257 - 259

Keywords

Case-Control Studies, Chromosomes, Human, Pair 11, Cohort Studies, Genetic Predisposition to Disease, Genetic Variation, Genotype, Ghana, Humans, Models, Genetic, Nuclear Proteins, Polymorphism, Single Nucleotide, Tuberculosis